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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKL
All Species:
40.91
Human Site:
Y643
Identified Species:
75
UniProt:
P17858
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17858
NP_002617.3
780
85018
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
V
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
V
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
Y715
T
D
F
I
F
N
L
Y
S
E
E
G
K
G
I
Dog
Lupus familis
XP_544922
751
82459
Y614
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
V
Cat
Felis silvestris
Mouse
Mus musculus
P12382
780
85282
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
R
G
V
Rat
Rattus norvegicus
P30835
780
85320
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
R
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514123
751
82475
Y614
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
I
Chicken
Gallus gallus
XP_001232621
780
85127
Y643
T
E
F
L
Y
N
L
Y
S
S
E
G
K
G
I
Frog
Xenopus laevis
NP_001091319
786
86623
Y646
T
D
F
I
Y
Q
L
Y
S
E
E
G
R
G
V
Zebra Danio
Brachydanio rerio
XP_698635
780
84600
Y643
T
D
F
I
H
K
L
Y
S
A
E
G
K
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
L652
S
T
D
F
I
Y
R
L
Y
S
E
E
G
K
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
K615
E
K
L
A
I
E
T
K
E
R
L
D
S
G
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
T821
G
K
L
I
L
K
S
T
N
A
S
K
A
L
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
63.8
90.1
N.A.
94
94.2
N.A.
86.6
86.7
68.4
77.5
N.A.
55.5
N.A.
40.1
N.A.
Protein Similarity:
100
99.6
77.3
93
N.A.
97.1
97.3
N.A.
91.9
93.8
83.7
89.6
N.A.
73
N.A.
58.2
N.A.
P-Site Identity:
100
100
66.6
100
N.A.
93.3
93.3
N.A.
93.3
93.3
66.6
66.6
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
100
100
86.6
93.3
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
16
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
24
8
0
0
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
8
54
0
0
0
8
0
0
8
16
85
8
0
0
0
% E
% Phe:
0
0
77
8
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
77
8
85
8
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
31
16
0
0
0
0
0
0
0
0
0
24
% I
% Lys:
0
16
0
0
0
16
0
8
0
0
0
8
54
8
0
% K
% Leu:
0
0
16
54
8
0
77
8
0
0
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
62
0
0
8
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
8
0
0
24
0
0
% R
% Ser:
8
0
0
0
0
0
8
0
77
62
8
0
8
0
8
% S
% Thr:
77
8
0
0
0
0
8
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
54
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
62
8
0
77
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _